KMID : 1149220020100020097
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Korean Journal of Oriental Medical Prescription 2002 Volume.10 No. 2 p.97 ~ p.112
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Yookmijihwang-Tang on the Plasma Corticosterone level in Mice exposed to Heat, Cold and Immobilization Stress
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Kang Young-Gun
Lee Tae-Hee
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Abstract
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In order to investigate the effect of Sagoonja-Tang, Samool-Tang and Yookmijihwang-Tang against the cold, heat and immobilization stress, each formula was injected intragastically to mice exposed to forced cold water swimming(4¡É), forced hot water swimming(42¡É) and immobilization stress before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. One hour after each Sagoonja-Tang, Samool-Tang, Yookmijihwang-Tang with the dose of 1g£¯kg, 3g£¯kg each were administered to mice, we put cold stress(4¡É) for 3 min. Samool-Tang(1g/kg) and Yookmijihwang-Tang(lg/kg) showed significant decrease of corticosterone level(p¡´0.01, p¡´0.05) but Sagoonja-Tang didn¡¯t change it. In the case of the dose of 3g/kg, only Samool-Tang decreased corticosterone level(P¡´0.01), but Sagoonja-Tang, Yookmijihwang-Tang didn¡¯t make significant effect on plasma corticosterone level of the mice exposed to heat stress(42¡É). 3. Those mice which exposed to immobilization stress one hour after Sagoonja-Tang, Samool-Tang, Yookmijihwang-Tang with the dose of 1g/kg and 3g/kg didn¡¯t show effective decrease of corticosterone level. However, Sagoonja-Tang(3g/kg), Samool-Tang(lg/kg, 3g/kg) showed the effect of mild increase of corticosterone level rather than decrease. These data revealed that the effect-variation of prescriptions depended on the kinds of stress and the dose of prescriptions had a different effect on therapy.
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KEYWORD
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